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MOTS-c

LongevityEvidence Level: researchNot FDA-approved for therapeutic use; available for research purposes only.
Peptide #30

MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids, naturally encoded within mitochondrial DNA. It is renowned for its potent effects on metabolic regulation, energy homeostasis, and overall cellular health. MOTS-c has attracted significant scientific attention for its potential therapeutic applications in metabolic disorders, aging, and physical performance enhancement.

Overview

MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids, naturally produced within human mitochondria, and widely recognized for its potent roles in regulating metabolism, energy balance, and overall cellular health.

How It Works

MOTS-c significantly improves mitochondrial function, optimizing cellular energy production and promoting efficient glucose metabolism. It enhances insulin sensitivity and supports metabolic homeostasis.

Clinical Effects

Improves metabolic function, enhances insulin sensitivity, supports energy efficiency, reduces oxidative stress, enhances cellular resilience, boosts mitochondrial energy output, enhances physical performance, endurance, and recovery from exercise-induced stress.

Therapeutic Applications

Metabolic disorders like obesity, diabetes, metabolic syndrome; anti-aging medicine; sports performance enhancement.

Research Studies

Clinical Trials

Initial human clinical trials have shown promising results regarding improved metabolism, insulin sensitivity, and enhanced physical performance.

Preclinical Studies

Early clinical trials and preclinical studies report significant improvements in metabolic function, insulin sensitivity, and physical endurance.

Frequently Asked Questions

Is MOTS-c legally available? Yes, MOTS-c is legally available for research purposes through specialized suppliers but is not FDA-approved for general therapeutic use. Have human trials been conducted with MOTS-c? Initial human clinical trials have shown promising results regarding improved metabolism, insulin sensitivity, and enhanced physical performance, but extensive research and clinical validation remain ongoing. What are potential side effects of MOTS-c? Reported side effects in preliminary studies are minimal and mild, typically transient in nature. Long-term safety profiles continue to be investigated. How is MOTS-c typically administered? MOTS-c is usually administered via subcutaneous injections in clinical research settings, with dosing protocols tailored to specific study objectives. Can MOTS-c be combined with other therapies? While MOTS-c is explored alongside other metabolic and performance-enhancing therapies, controlled studies are necessary to establish safe and effective combination protocols. Does MOTS-c provide permanent improvements? MOTS-c significantly enhances metabolic functions and physical performance during administration. Sustained therapeutic effects typically require ongoing or periodic treatments combined with lifestyle modifications.

Quick Information

Safety Information

Safety Profile

Long-term safety profiles continue to be investigated. Medical professionals emphasize the need for extensive clinical research to fully validate its safety.

Contraindications

Side Effects: Reported side effects in preliminary studies are minimal and mild, typically transient in nature. Safety Profile: Long-term safety profiles continue to be investigated. Medical professionals emphasize the need for extensive clinical research to fully validate its safety.

Side Effects

Reported side effects in preliminary studies are minimal and mild, typically transient in nature.

Research References

Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. Kim, S.J., et al. (2018). Mitochondrial-derived peptides as regulators of metabolism and aging. BMB Reports. Merry, T.L., & Ristow, M. (2016). Mitohormesis in exercise training. Free Radical Biology & Medicine.

Additional Resources