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Semax

NeuroEvidence Level: researchNot FDA-approved; ongoing research highlights its broad therapeutic potential in neuroscience and cognitive health.
Peptide #46

Semax is a synthetic heptapeptide analog derived from ACTH, specifically engineered to exert potent neuroprotective and nootropic effects. It influences various neurochemical pathways, including modulation of brain-derived neurotrophic factor (BDNF), dopaminergic, and serotonergic systems, improving cognitive function, memory, and emotional resilience.

Overview

Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH), renowned for its significant neuroprotective, cognitive-enhancing, and anxiolytic properties.

How It Works

Semax significantly improves cognitive performance by enhancing memory, attention, and learning capabilities. It supports neuronal survival and regeneration by reducing oxidative stress and inflammation within the brain. It modulates the brain’s response to stress by regulating levels of cortisol and other stress hormones.

Clinical Effects

Enhanced memory, improved focus, increased mental clarity, reduced oxidative stress and inflammation, improved outcomes in conditions such as stroke, traumatic brain injury, and neurodegenerative disorders, regulation of stress responses and anxiety, improved emotional resilience and overall mental health.

Therapeutic Applications

Cognitive decline, neurological recovery, mood disorders, stress-related conditions, stroke recovery, traumatic brain injuries, anxiety disorders, depression.

Research Studies

Clinical Trials

Limited human trials have demonstrated promising initial outcomes for cognitive enhancement, neuroprotection, and anxiety reduction.

Preclinical Studies

Preclinical studies demonstrate improvements in memory, learning, and cognitive resilience, alongside significant neuroprotective effects.

Frequently Asked Questions

Is Semax legally available? Yes, Semax is legally available for research purposes from specialized suppliers but is not approved for general therapeutic use. Have human trials been conducted with Semax? Limited human trials have demonstrated promising initial outcomes for cognitive enhancement, neuroprotection, and anxiety reduction. Comprehensive research is ongoing. What are potential side effects of Semax? Side effects are typically minimal and mild, such as transient irritation from intranasal administration. Long-term safety studies are necessary. How is Semax typically administered? Semax is commonly administered intranasally or via subcutaneous injections in research settings, with dosing protocols adjusted to specific research objectives. Can Semax be combined with other cognitive enhancers or neuroprotective agents? Semax is often studied in combination with other cognitive enhancers or neuroprotective treatments. Controlled research is essential to establish safe and effective protocols. Does Semax permanently enhance cognitive functions? Semax enhances cognitive functions and reduces anxiety during active administration. Ongoing or repeated treatments typically maintain sustained cognitive benefits.

Quick Information

Safety Information

Safety Profile

Strong safety profile; long-term safety studies are necessary.

Contraindications

Side Effects: Typically minimal and mild, such as transient irritation from intranasal administration. Safety Profile: Strong safety profile; long-term safety studies are necessary.

Side Effects

Typically minimal and mild, such as transient irritation from intranasal administration.

Research References

Ashmarin, I.P., et al. (1997). Semax, an ACTH(4-10) analogue with neuroprotective and cognitive enhancing properties. Neuroscience and Behavioral Physiology. Levitskaya, N.G., et al. (2004). Neuroprotective and nootropic properties of Semax, a synthetic ACTH(4-10) analogue. Neuroscience and Behavioral Physiology. Umriukhin, A.E., et al. (2001). Neurotropic effects of heptapeptide Semax. Neurochemical Journal.

Additional Resources