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Tesofensine

Weight LossEvidence Level: researchNot FDA-approved for general therapeutic use; ongoing clinical trials
Peptide #36

Tesofensine is an innovative pharmacological compound initially developed as a potential treatment for Alzheimer's and Parkinson's diseases due to its unique effects on neurotransmitter reuptake inhibition. Acting as a triple reuptake inhibitor, Tesofensine effectively blocks the reuptake of serotonin, noradrenaline, and dopamine in the brain, leading to elevated levels of these neurotransmitters. This mechanism significantly enhances satiety, suppresses appetite, and increases overall energy expenditure, making it particularly effective for weight loss and metabolic health improvement.

Overview

Tesofensine is an innovative pharmacological compound initially developed as a potential treatment for Alzheimer's and Parkinson's diseases due to its unique effects on neurotransmitter reuptake inhibition.

How It Works

Tesofensine increases extracellular levels of serotonin, noradrenaline, and dopamine by inhibiting their reuptake.

Clinical Effects

Substantial appetite suppression, enhanced energy expenditure, improved metabolic parameters, enhanced insulin sensitivity, improved mood, energy levels, and cognitive function

Therapeutic Applications

Obesity management, metabolic syndrome, prediabetes, obesity-related metabolic complications, cognitive impairment, Alzheimer's, Parkinson's diseases

Research Studies

Clinical Trials

Numerous human clinical trials have consistently reported promising outcomes in substantial weight loss, appetite suppression, and improved metabolic health.

Frequently Asked Questions

Is Tesofensine legally available? Tesofensine is legally available for research purposes from specialized suppliers but is not yet FDA-approved for general therapeutic use. Have human trials been conducted with Tesofensine? Numerous human clinical trials have consistently reported promising outcomes in substantial weight loss, appetite suppression, and improved metabolic health. Further comprehensive clinical validation is ongoing. What are potential side effects of Tesofensine? Commonly reported side effects include mild gastrointestinal disturbances, dry mouth, dizziness, and potential increases in heart rate and blood pressure. Ongoing studies are needed to fully evaluate long-term safety. How is Tesofensine typically administered? Tesofensine is typically administered orally in clinical research settings, with dosage protocols carefully tailored according to specific therapeutic objectives and patient needs. Can Tesofensine be combined with other treatments? Controlled clinical studies are necessary to safely evaluate potential combinations with other metabolic or weight management therapies. Does Tesofensine offer permanent weight loss? Tesofensine significantly promotes weight loss during active administration periods. Sustained benefits typically require ongoing treatments supported by lifestyle interventions.

Quick Information

Safety Information

Safety Profile

Ongoing studies are needed to fully evaluate long-term safety

Contraindications

Side Effects: Mild gastrointestinal disturbances, dry mouth, dizziness, potential increases in heart rate and blood pressure Safety Profile: Ongoing studies are needed to fully evaluate long-term safety

Side Effects

Mild gastrointestinal disturbances, dry mouth, dizziness, potential increases in heart rate and blood pressure

Research References

Astrup, A., et al. (2008). Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomized, double-blind, placebo-controlled trial. Lancet. Hansen, H.H., et al. (2010). Tesofensine induces appetite suppression and weight loss with limited cardiovascular side effects. International Journal of Obesity. Hughes, T.E., & Lee, M.J. (2008). Emerging therapies for metabolic diseases—the case for tesofensine. Expert Opinion on Investigational Drugs.

Additional Resources