Clinically Refined Hormone Support: Boost Testosterone with Fewer Side Effects

Content provided by Strive Pharmacy

Enclomiphene citrate represents a refined advancement in men’s hormonal therapy. As the active trans-isomer of clomiphene, enclomiphene provides a more targeted and predictable approach to improving testosterone levels in men with secondary hypogonadism.

Unlike clomiphene — which acts as both an agonist and antagonist on estrogen receptors — enclomiphene functions purely as an estrogen receptor antagonist, allowing for a cleaner stimulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production. This results in a natural increase in testosterone without significantly elevating estrogen or compromising fertility [1] [2].

• Targeted Hormonal Modulation: Increases LH and FSH levels while minimizing estrogen feedback on the hypothalamus and pituitary [1] [2].
• Reduced Side Effects: Compared with clomiphene, enclomiphene shows fewer reports of mood changes, gynecomastia, and visual disturbances [2].
• Fertility-Preserving: Boosts testosterone while maintaining sperm production.
• Rapid Adjustment Capability: Allows tight hormonal control and reduced estrogen sensitivity [2].
• Refined Estrogen Control: Acts exclusively as an estrogen receptor blocker, ideal for men with estrogen-sensitive symptoms.

Note: Enclomiphene is not effective in primary hypogonadism where LH levels are already elevated.

At Strive Pharmacy, enclomiphene is available in flex-dose tablets designed for precision, convenience, and optimal patient outcomes.

• Enclomiphene 12.5 mg tablet: Adjustable to 3.125 mg, 6.25 mg, 9.375 mg, or 12.5 mg.
• Enclomiphene 25 mg tablet: Adjustable to 6.25 mg, 12.5 mg, 18.75 mg, or 25 mg.

Advantages:

• Customizable for fine-tuned hormone response.
• Optimized outcomes with gradual titration to reach the therapeutic sweet spot.
• Flexible dosing schedule—typical range 6.25 mg to 25 mg, daily or every other day.
• Tablets are preferred over capsules for precision dosing; capsule options available upon request.

• Headache or mild nausea.
• Occasional visual disturbances (less frequent than clomiphene).
• Mild gynecomastia (lower incidence vs. clomiphene).
• Occasional mood swings (less prevalent than clomiphene).

1. Wiehle R, Cunningham GR, Pitteloud N, et al. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism. BJU Int. 2013;112(8):1188–200.
2. Saffati G, Kassab J, Rendon DO, et al. Enclomiphene vs. Clomiphene: Safety and Testosterone Levels in Hypogonadal Men. J Urol. 2024;211(5S):e762.